Category: Portfolio Updates

  • Breaking the Prior Authorization Bottleneck: How RISA Labs is Transforming Healthcare

    Breaking the Prior Authorization Bottleneck: How RISA Labs is Transforming Healthcare

    In an era when AI-driven advances promise to transform healthcare, one of the simplest tasks still trips up clinicians and stalls patient care: prior authorization. Designed as a safety net to verify medical necessity, PA has become a Gordian knot of faxed forms, phone trees, and opaque payer rules. Patients wait weeks for approval, clinicians burn out on paperwork, and the system bleeds over $80 billion in wasted labor annually.

    RISA Labs isn’t just building another bolt-on shortcut. They’re rewriting the PA playbook with an end-to-end, AI-powered orchestration engine that treats authorization as a seamless clinical workflow, not a bureaucratic burden. Below, we explore the human cost of today’s PA grind, how RISA Labs is engineering a radically different experience, and why this shift matters for every patient and provider.

    The Broken Backbone of Clinical Care

    Imagine a cancer center where every treatment path hinges on a pre-clearance form. At one leading U.S. oncology practice, physicians report that 70 percent of patients face PA delays, and one in three wait over a month time during which certain cancer mortality risks climb by 1.2 – 3.2 percent per week of delay. Those delays aren’t just statistics; they’re missed chemotherapy cycles, frantic phone calls, and families in limbo.

    In behavioral health clinics, the story is no less grim. Providers spend 24 minutes and up to $14 per authorization, i.e., three times the effort of general-medicine cases to navigate transfer forms, fax confirmations, and appeal letters. Across the system, prior authorization volumes have surged 27 percent since 2016, yet fully electronic automation barely budged, forcing staff to shoulder growing caseloads manually.

    For practices, the result is staff burnout and costly errors; for patients, it’s delayed diagnoses, interrupted therapies, and, in the worst cases, preventable harm. Nearly 30 percent of radiation oncologists report that PA has directly led to hospitalizations or emergency visits and 7 percent say it even contributed to patient deaths. This tangled process undermines care, erodes clinician morale, and drives up healthcare costs at every step.

    Turning Prior Authorization into a Co-Pilot

    In 2024, Kshitij Jain and his co-founders recognized that true transformation required more than incremental automation. They launched RISA Labs with a clear thesis: clinical operations deserve a unified, intelligent backbone. One that combines AI’s speed with human judgment where it matters most.

     

    Risa Labs Cofounders: Kshitij Jaggi & Kumar Shivang

     

    At the heart of their solution is BOSS – Business Operating System as a Service. Rather than scattered bots or static rule engines, BOSS uses a multi-agent AI framework to parse each PA request: large-language models extract clinical details from notes; machine-learning classifiers match those details to payer guidelines; robotic-process automation submits forms and uploads documentation; and a human overseer steps in only when complexities arise. The result? What once took 30–45 minutes collapses into a five-minute, 80 percent-automated journey with error rates dropping by more than half in early oncology trials.

    Crucially, RISA Labs built deep EHR and clearinghouse integrations from day one, connecting to Epic, Athenahealth, Cerner, and Availity so that PA becomes a natural extension of the clinical chart, not a separate silo. And because the system learns from each case, reinforcing successes and flagging exceptions, BOSS grows more accurate over time, paving the way for an AI co-pilot capable of handling not just authorization but referrals, imaging orders, and beyond.

    The Road Ahead: From Choke-Point to Clinical Flywheel

    RISA Labs envisions a future where prior authorization is no longer a painful afterthought but an invisible partner in every clinician’s workflow. In the coming months, BOSS will quietly extend its reach beyond oncology—seamlessly handling imaging orders in radiology suites, orchestrating referrals in cardiology clinics, and managing pharmacy benefits behind the scenes. Clinicians will log into the same familiar EHR, only to discover their PA tasks already underway: requests parsed, guidelines applied, forms submitted, and approvals delivered—often before the next patient arrives in the exam room.

    As BOSS learns from each case, its AI agents will grow more confident and autonomous, resolving an ever-greater share of requests without human intervention. At the same time, RISA Labs will forge deep ties with payers themselves, integrating real-time policy engines so that every shift in coverage criteria instantly recalibrates BOSS’s decision logic. This fluid exchange will not only keep authorizations accurate but anticipate changes—alerting care teams to evolving requirements or newly covered therapies before those policies even reach the fax machine.

    Behind the scenes, RISA Labs is already partnering with academic centers to measure the clinical impact of this transformation. Soon, peer-reviewed studies will show how BOSS-driven authorizations shave days off treatment start times, reduce hospital readmissions, and even improve patient survival rates. And as those data points accumulate, they will do more than prove ROI—they will build trust across the healthcare ecosystem, opening doors to new collaborations, deeper integrations, and ultimately a unified, AI-powered operating system that transforms every corner of clinical operations.

    In that future, administrative burden gives way to clinical focus, patient access accelerates, and the promise of intelligent healthcare delivery becomes reality. RISA Labs isn’t just automating tasks—it’s redefining what care can look like when technology works for clinicians, not against them.

    By reframing prior authorization as a seamless, intelligent workflow rather than a hulking administrative hurdle, RISA Labs is digitizing not just tasks but trust—freeing clinicians to focus on patients and accelerating access to the treatments that save lives. In doing so, they’re lighting the path toward a future where healthcare operations are as smart and compassionate as the medicine they enable.

     

  • Engineering Silence: Greenjets and the New Sound of Aviation

    Engineering Silence: Greenjets and the New Sound of Aviation

    Too Much Noise, Too Little Flying

    Above bustling city streets, delivery drones and eVTOL air taxis now carve invisible corridors through the sky yet for many residents, their distinctive whine is neither futuristic nor welcome. Laboratory and field studies show that typical open-rotor electric motors emit sharp, high-frequency tones that carry further in urban canyons, triggering complaints and stress responses akin to those first documented by the EPA in the late 1970s. Even when marketed as “quieter than helicopters,” many systems still exceed local noise thresholds, prompting city councils to pause pilot programs and redraw flight paths at community hearings.

    Beneath the din lies a more fundamental constraint: energy density. Jet A fuel boasts roughly 12,000 Wh/kg, whereas state-of-the-art lithium-ion battery packs deliver barely 200–300 Wh/kg. This disparity forces designers to trade off range and payload against the added weight of batteries, confining electric platforms to short hops and niche surveillance roles rather than reliable point-to-point transport. While next-generation chemistries like solid-state, lithium-sulfur promise incremental gains, they face rigorous safety, cost, and scaling hurdles before they can match jet-fuel benchmarks.

     

    On top of this, certification adds another layer of complexity. The FAA’s new “powered-lift” rule, finalized in October 2024, outlines a path for eVTOL aircraft, but the multi-stage type-certification process remains lengthy and resource-intensive. Joby Aviation’s recent progress in navigating three of five certification steps over several years highlights both promise and persistent uncertainty. Evolving safety standards, data requirements, and flight-test regimes deter some investors and compel OEMs to stretch out funding rounds, slowing the pace from prototype to revenue-generating fleets.

     

    Finally, the materials at the heart of electric motors remain a strategic vulnerability. Neodymium-iron-boron magnets require rare-earth oxides, over 80 percent of which are processed in China. When Beijing expanded export controls in 2023, curbing not only mined minerals but also finished magnet products global manufacturers felt immediate reverberations. Diversification efforts in Australia, the U.S., and recycling can mitigate risk, but developing alternative supply chains and processing capacity is a multi-year, capital-intensive endeavor.

     

    Together, these intertwined barriers – acoustic pollution, low battery energy-density, murky certification pathways, fragile community trust, and geopolitically fraught materials keep electric aviation grounded. Addressing them in silos will never suffice; the next leap requires propulsion systems engineered holistically for silent operation, optimized efficiency, regulatory alignment, transparent impact modeling, and supply-chain resilience. Only then can the vision of truly quiet, clean, and scalable flight take off.

    Rethinking Propulsion For The New Era

    Most electric aviation systems flying today weren’t built for the skies they now occupy. They borrow from hobbyist designs or industrial-grade rotors, resulting in propulsion that is loud, inefficient, and fundamentally ill-suited to life above cities. These open-rotor setups hum with high-frequency noise; piercing enough to disrupt neighborhoods, loud enough to stall community acceptance, and messy enough to make regulators hesitate.

    Greenjets took a different path.

    From day one, the team chose not to retrofit the past, but to build for the world ahead designing electric ducted-fan systems from the ground up. Their technology doesn’t just look cleaner; it sounds like it. By enclosing rotors and engineering airflow with surgical precision, Greenjets has achieved acoustic signatures up to 10× quieter than open-rotor equivalents without compromising on thrust or control. In urban air mobility, where public trust often hinges on decibels, that difference is more than technical, it’s cultural.

     

     

    This innovation is more than skin deep. Instead of bolting together off-the-shelf fans and battery packs, Greenjets has reimagined the propulsion module as a tightly integrated system: cooling, structure, and control working together as one unit. That vision became reality in early 2023, when Greenjets unveiled the world’s first electric jet engine demonstrator built specifically for commercial drone platforms. It wasn’t just a breakthrough in performance. It was proof that safety, certification, and silence could be engineered not as trade-offs, but as table stakes. And they couldn’t have timed it better.

    As aviation faces unprecedented pressure to decarbonize, battery technology is catching up, short-haul routes are opening up, and regulators are finally aligning behind eVTOL certification frameworks. Cities are laying the groundwork for aerial corridors but grounding noisy operators. In parallel, defense agencies are seeking next-gen drones that are stealthier, more agile, and energy efficient.

    Greenjets fits squarely into this moment. Especially as geopolitical fault lines sharpen and rare-earth dependencies become liabilities. In April 2025, China tightened export controls on critical magnet materials, sending a shockwave through global EV and aerospace supply chains. But Greenjets had already made the hard choice: to avoid reliance on Chinese rare-earths altogether, sourcing instead from emerging suppliers in the West and Australia. That decision, once contrarian, now feels prescient.

    Behind the product is a team that knows propulsion to its core. CEO Anmol Manohar brings deep experience from Rolls-Royce and Formula 1, blending engineering rigor with high-speed iteration. Dr. Guido, formerly at BAE Systems, leads development with expertise in advanced turbomachinery and simulation. Together, they’ve built a team that moves fast without cutting corners—balancing aerospace-grade safety with startup-grade urgency.

     

     

    Supporting them is a circle of experienced advisors, including industry veteran Colin Smith, whose leadership in global aviation programs brings the kind of perspective that only decades at the frontier can provide.

    The result is a company that doesn’t just build electric engines, it’s rewriting the template for how electric flight should sound, feel, and scale.

    The Flight Ahead

    Greenjets isn’t just building engines, it’s building belief.

    Belief that the sound of flight can fade into the background. That clean, quiet propulsion isn’t a long-term goal but it’s ready for testing, for integration, for the skies.

    This isn’t a theory. In March 2024, Greenjets and Ricardo unveiled the InCEPTion demonstrator; a fully integrated, ducted-fan propulsion system built for aircraft under five tonnes. It was a step toward flight that is quiet, scalable, and certifiable.

     

     

    And the work continues. Through a research partnership with the Whittle Laboratory at Cambridge, Greenjets is combining engineering with climate modeling, exploring not just how to fly quieter and cleaner, but how to prove it scientifically, publicly, and at scale. In parallel, collaborations with edge-focused partners like Firestorm Labs are pushing the platform into the field, testing how modular units can perform in the real world, under real constraints.

    This is what momentum looks like.

    But perhaps most importantly, Greenjets is doing this without shortcuts with no rare-earth reliance and no supply-chain guesswork. In a world increasingly wary of fragility, the team is building with resilience in mind sourcing consciously, manufacturing locally, and preparing for a future where propulsion isn’t just cleaner, but smarter and more sovereign.

    For the industry, the signals are clear: certification frameworks are maturing, battery tech is catching up, and cities are preparing the infrastructure. What’s been missing is propulsion that meets the moment—with the performance, the silence, and the trust to scale.

    Greenjets is building exactly that. And they’re not waiting for the future to arrive. They’re flying toward it.

  • Z21 Ventures announces investment in Basepair, a SaaS platform that democratizes access to, analysis of, and interpretation of genomic data

    Z21 Ventures announces investment in Basepair, a SaaS platform that democratizes access to, analysis of, and interpretation of genomic data

     

    Thanks to advances in next-generation sequencing (NGS) technology, genomic data is being generated on an unprecedented scale. Improvements in cloud computing resources have allowed the raw data to be processed and stored with ever-increasing efficiency. However, analyzing this data and gaining insights from it is still very challenging and limited to a select few due to technology restrictions. This results in reduced efficiency for R&D teams, longer times to market for assay manufacturers, and increased turnaround times in clinical settings.

     

    Basepair, a software-as-a-service (SaaS) platform, democratizes access to and the analysis and interpretation of genomic data. Basepair allows organizations to connect to and leverage the compute and storage resources in their own cloud account, allowing them to optimize their resources and realize greater business value. This allows them to remain connected to the other analytical capabilities offered by their cloud provider while benefiting from economies of scale by running everything through one account. This enables the end users with the appropriate domain expertise to run the same workflows in a controlled setting and use the inbuilt visualization tools and reports to make sense of the data.

     

    Z21 Ventures is pleased to announce our strategic investment in Basepair. This investment reflects our commitment to supporting innovative solutions and purposeful companies. Basepair aligns seamlessly with our vision, providing an innovative solution that makes bioinformatics easier, faster, and cost-effective.

     

    “z21 is more than just an investor; it’s a team of builders and operators. From the start, the investment process was efficient and well-managed. They have connected us with top-tier investors and talent in Silicon Valley. Behind the scenes, they actively help improve the business from the ground up. z21 should be the top choice for any founder.” – Amit U Sinha | Founder & CEO of Basepair

     

    We are thrilled about the investment and the upcoming collaboration with Basepair and the vibrant Z21 community. We eagerly anticipate the opportunity to work closely with the Basepair team, leveraging our collective expertise to propel them toward even greater heights in the genomics industry.

     

  • z21 ventures announces investment in FlashAid, a healthcare technology platform democratizing healthcare for masses in India

    z21 ventures announces investment in FlashAid, a healthcare technology platform democratizing healthcare for masses in India

     

    FlashAid is democratizing healthcare coverage by offering affordable health coverage to millions in India. It offers a unique membership plan that covers hospitalization expenses and Primary benefits such as teleconsultation, labs, diagnostics, and home care services. FlashAid is a healthcare technology platform that partners with various healthcare service providers to bring the best care you deserve at an affordable price.

     

    The retail health insurance market is one of the fastest growing segments with a CAGR of 18% and is expected to touch $25B by 2028. Founded by Manoj Gupta and Gunjali Kothari, FlashAid is working on exclusive tie-ups with insurance companies to tailor-make products and partner with e-commerce platforms and brands to distribute insurance to their users. The company offers a full-stack health solution with proprietary pre-underwritten products, open APIs, and embedded solutions.

     

    ” With an expected 30% surge in digital platform adoption by 2030, a significant opportunity emerges to align the ecosystem towards providing scalable solutions that promote health equity in India. We’re actively embracing this digital evolution through our API-centric strategy, which resonates with customers’ shifting behaviors in purchasing and accessing healthcare services. This approach aims to make the healthcare ecosystem more accessible and user-friendly, benefiting the wider population”. – Manoj Gupta | Founder & CEO, FlashAid

     

    Its distributive technology has made traditional retail Insurance cheaper by 70% and solves complex onboarding and tedious claim processing. With personal retail Health Insurance penetration of less than 4% in India, FlashAid ‘s unique B2B2C distribution approach makes it highly scalable, keeping the acquisition cost low. Within just 1 year of launch, they have 30,000+ lives already on board and are expected to cross 100K lives in another 6 months.

     

    z21 ventures is excited to announce our investment in FlashAid. Its scalable embedded insurance product with a comprehensive healthcare offering provides a unique value proposition for expanding the healthcare insurance market globally. 

  • z21 ventures announces investment in vHub, an AI-driven SaaS platform revolutionizing the influencer marketing industry

    z21 ventures announces investment in vHub, an AI-driven SaaS platform revolutionizing the influencer marketing industry

     

    The influencer marketing industry, currently valued at $13.8 billion globally, is projected to grow exponentially. However, brands and enterprises are still challenged with influencer discovery, navigating influencer authenticity, and optimizing the ROI of influencer marketing campaigns.

     

    vHub.ai is revolutionizing the influencer marketing industry by making it more data-driven and insightful. Founded in 2021, the company’s AI-driven SaaS platform empowers brands and advertisers with deeper insights into their target audiences on platforms like Instagram, YouTube, and LinkedIn. It provides tools for easily discovering the right content creators and effective strategies, enabling brands to optimize and precisely target their visibility on these social media platforms.

     

    z21 ventures is pleased to announce our strategic investment in vHub.ai. This investment reflects our commitment to supporting innovative AI-driven SaaS platforms. vHub.ai’s offerings include an AI-powered influencer discovery engine, fraud detection tools, a detailed ROI dashboard, a comprehensive influencer marketing campaign management suite, a marketplace for brands and influencers to connect, and an audience dashboard for brands to analyze their presence on social media platforms.

     

    “Partnering with z21 Ventures has validated our vision and fueled our growth, providing capital and access to invaluable advice from a supportive community of mentors and industry leaders. z21 is also instrumental in enhancing our Go-To-Market strategy and connecting us with expert advisors, further driving our innovations in influencer marketing.”- Sachin Modi | Co-founder & CEO of vHub.AI

     

    We are excited about the investment and collaboration with vHub.ai and the z21 community, and we look forward to working closely with the vHub.ai team to propel them toward even greater heights.

  • z21 ventures announces investment in CoverSelf, a healthcare-specific, next-gen, cloud-native, and customizable claims accuracy platform.

    z21 ventures announces investment in CoverSelf, a healthcare-specific, next-gen, cloud-native, and customizable claims accuracy platform.

     

    The complex US healthcare system is wasting hundreds of millions of dollars on bureaucracy because of poor data and a lack of transparency. Administrative expenses account for almost a quarter of the $4.1 trillion spent on healthcare in the US each year. Improvements in automated claims processing, data accuracy, and transparency could therefore release huge savings for providers and payers alike, freeing up cash to fund healthcare improvements.

     

    CoverSelf’s healthcare-specific, next-gen, cloud-native, and customizable claims accuracy platform is built from the ground up using modern software development techniques. It empowers users’ long-term success by smoothly adapting to ever-evolving, dynamic claims, and payment inaccuracies, reducing complexities and administrative costs.

     

    z21 Ventures is pleased to announce our strategic investment in CoverSelf. This investment reflects our commitment to supporting innovative solutions and purposeful companies that reshape healthcare IT. CoverSelf aligns seamlessly with our vision, providing an innovative payment integrity solution that addresses payment leakage and claims inaccuracies while remaining transparent and accessible to payers.

     

    “The team and community has hands-on business experience, deep understanding of healthcare and enterprise software, and extensive industry connections make them invaluable assets for startups seeking more than just funding.” – Rajasekhar Maddireddy | Founder & CEO of Coverself

     

    We are excited about the investment and collaboration with CoverSelf and the z21 community, and we look forward to working closely with the CoverSelf team to propel them toward even greater heights. 

  • Announcing our investment in Zime, AI-first sales content and training

    Announcing our investment in Zime, AI-first sales content and training

     

    Sales cycles can be complex and as reps spend time on several pieces of fragmented content, training, and unstructured information, Zime AI distills all these into a unified taxonomy of actions for sellers and win-loss insights for marketing and revenue teams. 

    At z21, we are excited about our partnership with Zime, to supercharge sellers with valuable insights and just-in-time actions and help them close more deals and do that faster. By bringing the power of Gen AI and behavioral science, we believe sales performance can be tangibly enhanced with Zime’s disruption solution.


    Zime AI is powered by company-specific sales data, and generates personalized content, replacing traditional training and providing strategic insights from numerous customer interactions. We envision a future where sales teams are armed with actionable intelligence, unique to their sales cycles, products & markets.

     

     “Building a company needs a village. To supercharge my growth, I was looking for investors who have been SaaS operators and have built large companies. I loved every interaction with the z21 team & how they are helping us think ahead.” – Sanchit Garg, Founder & CEO, Zime

     

    We are excited about the investment in Zime and we look forward to working closely with the Zime team to propel them toward even greater heights.

  • Announcing z21 Ventures investment in Meomind, the scalable alternative to psychotherapy

    Announcing z21 Ventures investment in Meomind, the scalable alternative to psychotherapy

     

    Outpatient psychotherapy is a $50Bn global market and $25Bn+ is spent on outpatient mental therapy every year in the US. Despite a widespread, growing, and acute need for therapy solutions, there isn’t a single one that is accessible in a timely way, affordable, and effective in driving clinical outcomes. Users need to wait for weeks to get in touch with a therapist who may or may not be the right fit for them. This significantly delays the process of seeking help and worsens the symptoms for many users. 

     

    z21 Ventures is pleased to announce our strategic investment in Meomind. By uniquely creating a vast library of pre-recorded therapy sessions, Meomind is on the path to providing on-demand access to high-quality relatable solutions to millions of users. With 70k+ members on the platform, 80% of members have reported feeling better in 2.5 weeks. This makes Meomind a great benefit that employers and health plans can offer to support the mental well-being of members.

     

    This partnership is a testament to our belief in the role of technology to make effective mental well-being solutions accessible to all. Meomind partners with world-class therapists to curate therapy sessions relatable to diverse scenarios.

     

    “The entire z21 team has been incredibly helpful in connecting us to a rich network of GTM experts, technologists, and investors. z21 has built a unique value proposition with the vast reach of its LPs who not only have deep expertise but are also very generous with their time and advice.” – Sushant Gupta, CEO, Meomind

     

    We look forward to working closely with Sushant and the Meomind team to disrupt the mental health landscape.

  • Announcing z21 Ventures investment in Rexera (formerly InspectHOA), an AI-powered solution for streamlining real estate closings.

    Announcing z21 Ventures investment in Rexera (formerly InspectHOA), an AI-powered solution for streamlining real estate closings.

     

    Rexera, formerly InspectHOA, is a leading provider of HOA documents acquisition and modernized settlement processes for the real estate industry. It is known for its flagship HOA service, which helps title and escrow companies, underwriters, real estate attorneys, mortgage lenders, and investors avoid the difficulties that come with dealing directly with HOAs in the closing process. 

     

    Using a combination of the largest database in the country, AI technology, and HOA professionals, Rexera offers HOA and condo documents acquisition and analysis services, municipal lien search, mortgage payoff, and asset management solutions which lead to faster closing times, seamless asset management, lower error rates, higher customer satisfaction, and employee engagement.

     

    z21 Ventures is pleased to announce our strategic investment in Rexera. This partnership reflects our commitment to supporting innovative solutions that reshape the future of work. Rexera aligns seamlessly with our vision, providing innovative, reliable, and inclusive services that revolutionize the real estate market. Rexera’s AI Co-pilot has the potential to transform the real estate closing process and reduce the time-to-close. 

     

    We are excited about the positive impact this collaboration will bring, and we look forward to working closely with the Rexera team to propel them toward even greater heights. Together, we embark on a journey of accelerating real estate workflows.

  • Announcing z21 Ventures investment in Develo, the modern operating system for pediatrics

    Announcing z21 Ventures investment in Develo, the modern operating system for pediatrics

     

    Despite annual spending of $410B+ for ~113M patients annually in the United States, traditional electronic medical record (EMR) systems overlook the uniquely family-centered, relationship-driven, and high-volume nature of outpatient pediatric care. The adult-first approach of legacy systems significantly impacts practice performance, with many facing patient throughput and claim denials challenges. Rising value-based care, consumerism, and regulatory headwinds add more pressure on independent practices to modernize their technology stack– but traditional EMRs lack the foundations to meet those emerging needs.

     

    Develo sets the new standard for pediatric software tailor built for independent pediatric practices.

     

    z21 Ventures is pleased to announce our strategic investment in Develo. By uniquely combining EMR and customer relationship management (CRM) capabilities, Develo boosts practice net revenues by 20% and saves ~10 hours a week per practice user. Standout features such as charge capture automation, AI-enabled clinical documentation, automated family outreach, and pediatrics task management significantly improve practice productivity and family satisfaction with their care.

     

    This partnership reflects our deep belief in the role of modern technology in driving transformative, world-class experiences for pediatricians, patients, and their families. Develo is not just a better pediatric EMR, but the first end-to-end operating system for pediatrics. FHIR-native interoperability and frictionless e-fax, e-prescribe, and e-lab integration foundations have real potential to future-proof pediatric practices.

     

    We look forward to working closely with the Develo team on their journey to disrupt pediatric care and improve child health.